Archive for January, 2012
Good news for hESC trials: transplanted human embryonic stem cell-derived retinal pigment epithelium… and it’s safe!
As has been reported broadly this week, transplantation of human embryonic stem cell-derived retinal pigment epithelial cells appears to be safe in human patients, and it may even be efficacious (although this can only be confirmed via a Phase II trial). Advanced Cell Technology (of California) published a preliminary clinical report of their Phase I…Read more
Repurposing known drugs for new applications is a strategy with fascinating potential, with two of the most notable examples being Thalidomide and Viagra. Thalidomide was commonly used in the late 1950s as a sedative in pregnant women, later being associated with serious birth defects. Today, it is used to treat multiple myeloma. Viagra was being…Read more
Yesterday, a landmark paper emerged from Cell which reported two major findings to the scientific community: Primate embryonic stem cells cannot generate chimeras, and Aggregation and injection of multiple early-stage four-cell primate embryos (not embryonic stem cells) can form chimeras. Together these findings underscore a fundamental difference between rodent and primate embryonic stem cell lines…Read more