Archive for August, 2012

Airway epithelial cells created from human patients could provide a powerful drug-screening tool for Cystic Fibrosis

Author: Angela C. H. McDonald, 08/30/12

If you tuned into the evening news on Monday night (at least here in Canada), you would have seen my PhD supervisor Janet Rossant, discussing a recent advancement in stem cell differentiation. Amy Wong, post-doctoral fellow in the Rossant lab, created a protocol for differentiating human pluripotent stem cells into mature airway epithelial cells. The…Read more

Redefining a cure: What a stem cell therapy for HIV reminds us about clinical translation

Author: Holly Wobma, 08/22/12

With over 34 million people living with HIV, of which only the fortunate have continual access to life-saving anti-retroviral drugs, it comes as no surprise that the recent media announcement of a potential “cure” for HIV went rapidly…well…viral. The excitement spurred from the XIX International AIDS Conference held in Washington DC (July 22-27, 2012) during…Read more

The Commercialization of Regenerative Medicine: Turning Corners

Author: Natasha Davie, 08/16/12

The health-care landscape is changing: the previous model of the blockbuster pharmaceutical is being challenged by new therapies that have the potential to offer more effective treatments. In this new contribution to Signals Blog, I describe the present landscape for regenerative medicine commercialization. The current health-care system is being pushed to the brink. Driven by…Read more

Scientists lose the paper cranes and become experts in nucleic acid origami for siRNA delivery

Author: Angela C. H. McDonald, 08/13/12

It takes precision, focus and persistence to perfect the art of origami. So perhaps it is no accident that researchers have needed to apply the same skills to overcome challenges in siRNA delivery, right down to the folding. A couple of years ago, my fellow blogger Paul Krzyzanowski introduced us to RNA interference (RNAi) technology….Read more