Paul Krzyzanowski

Paul is a computational biologist and writer living in Toronto. He’s been a contributor to Signals for three years, writing articles for the general public about how biotechnology and biomedical research can be used to solve pressing medical problems.

Alongside Paul’s experience in computational biology,
 bioinformatics,
and molecular genetics, he’s interested in how academic research develops into real world, commercial technology, and what’s needed for the Canadian biotech industry needs to grow.

Paul is currently a Post-doctoral Fellow at the Ontario Institute of Cancer Research. Prior to joining the OICR, he worked at the Ottawa Hospital Research 
Institute and earned a Ph.D. from the University of Ottawa, specializing in computational biology. And finally, Paul earned an H.B.Sc. from the University of Toronto a long time ago.

Paul’s blog can be read at www.checkmatescientist.net

Posts by: Paul


Why the pen is sometimes mightier than the pipette – Part 2

Author: Paul Krzyzanowski, 04/16/13

. Last week I posted a summary of the first half of a full day Communications for Scientists workshop organized by the Stem Cell Network. This post picks up where I left off, with a description of a “Dragon’s Den” style pitch session intended to introduce trainees to necessary communications skills within a commercialization context. The…Read more

Why the pen is sometimes mightier than the pipette – Part 1

Author: Paul Krzyzanowski, 04/10/13

. If Edward Bulwer-Lytton were a biologist two centuries ago, he might have quipped that the pen is mightier than the pipette instead of immortalizing the sword in his expression. Yet phrases emphasizing the power of words have been around for nearly three thousand years and are more relevant to your science than you might…Read more

Update: $600M insider trading fine is largest ever

Author: Paul Krzyzanowski, 03/16/13

. As a follow up to last month’s post describing how leaked information about an Alzheimer’s drug clinical trial led to the largest ever case of insider trading and destroyed the careers of Dr. Sidney Gilman, a well-respected clinician, and Matthew Martoma, a young stock trader, the Securities and Exchange Commission has just levied the…Read more

BioTime: A new Geron, without a decade of baggage

Author: Paul Krzyzanowski, 03/13/13

Avid watchers of the stem cell and regenerative medicine market have no doubt heard of Geron selling its stem cell assets to BioTime. Nature covered it in some detail last month, and the transaction itself follows a Letter of Intent announced last November, which valued it at approximately $71 million. The transaction leaves Geron to…Read more

High stakes: Unpublished research brings big profits and huge losses – to insider traders

Author: Paul Krzyzanowski, 02/14/13

- Nature kicked off 2013 with an unsettling article about how privileged information from research studies is being used to garner gigantic returns for investors, large and small. It’s not surprising, considering that one of the most egregious cases of so called academic information being used for insider trading of stock in public companies, Elan…Read more

Innovation without protection is philanthropy

Author: Paul Krzyzanowski, 01/08/13

This year, your household will pay $360 for the use of Intellectual Property (IP) held by people and corporations outside of Canada. For a little less than a dollar a day, you’re supporting industries like biotechnology, high-tech electronics, and engineering in other countries. Two policy think-tanks believe it’s time for Canadians to flip that balance…Read more

What if the game changes again? Perfect ES models in sight

Author: Paul Krzyzanowski, 11/21/12

  While the 2012 US election was in full swing, I reminded readers that despite the dominance of the world’s economic problems in this cycle, stem cell research was a political issue that hadn’t completely gone away.Methods to generate induced pluripotent stem cells (iPS cells) have constantly improved over the past few years, elegantly positioning…Read more

Stem cells: The quiescent issue in US elections

Author: Paul Krzyzanowski, 09/20/12

As 2012 slowly creeps on we can finally see November’s Presidential Election in the United States on the horizon marking the end of a nineteen month-long election process, which feels like an eternity compared to Canada’s last election, which lasted all of 38 days. Yet during all this time, debates regarding stem cell research — one of the…Read more

Drug giants filling in the Valley of Death

Author: Paul Krzyzanowski, 07/17/12

Faced with patent shortages to replace flagship products, Big Pharma is increasing investments in smaller biotech companies to capture innovations early. Most new companies wither and die if they run out of initial funds before they’re profitable.  In biotech, companies may strive to hit goals such as proving that a technology works as intended, developing…Read more

Cells as drugs: Health Canada approves mesenchymal stem cell based treatment

Author: Paul Krzyzanowski, 05/22/12

Many readers may already have heard of Health Canada’s approval of Osiris’ Prochymal, a mesenchymal stem cell treatment for severe cases of pediatric Graft versus Host Disease (GvHD), with plenty of coverage circulating around the web. GvHD is a disease where transplanted bone marrow generates an immune system that attacks cells of the recipient.  The…Read more