Posts Tagged ‘diabetes’

Interspecies generation of insulin producing cells now a reality

Author: David Kent, 03/01/17

From science fiction novelists through to medical doctors and industry leaders, a huge amount of attention has been given to the idea of growing human organs for transplantation in large farm animals like pigs and sheep. The need for organs to transplant into patients is one driving motivation (~5000 patients waiting in Canada alone), but…Read more

Update from the Clinic: March

Author: Mark Curtis, 04/28/16

Welcome to your Update from the Clinic for the month of March. Undoubtedly the big news in March came from Vericel, which saw its stock double after reporting positive topline results from its Phase 2b study in heart failure. There were also some first dosings and clinical study starts. A study of Vericel’s (VCEL) ixmyelocel-T…Read more

Cell Therapy Deal Review: September

Author: Mark Curtis, 10/20/15

. Welcome to your Cell Therapy Deal Review for the month of September. Aduro Biotech went the way of Juno and Kite and bought an antibody discovery platform. Intrexon and ZIOPHARM entered into an agreement to develop a novel Treg-based immunotherapy for GvHD. Kite Pharma expanded its relationship with the Netherlands Cancer Institute to develop…Read more

Cell Therapy Deal Review: July

Author: Mark Curtis, 08/18/15

. Welcome to your Cell Therapy Deal Review for the month of July. Here at Signals we’ve decided to change the name of this monthly column, to pay consideration to the fact the majority of the technologies discussed here are cell-based. Moving forward, I will continue to focus on the cell therapy industry specifically, but…Read more

A high school student rethinks science career options after StemCellTalks

Author: Guest, 07/06/15

. StemCellTalks is a Canadian high school outreach initiative that has been running in seven Canadian cities since 2010. The annual symposia were established to facilitate knowledge transfer between academia and high school students pertaining to the science and practical ethics of stem cells. To date, over 500 graduate student and trainee volunteers have reached…Read more

Cracking the code of pancreatic development: beta cells from iPS cells

Author: Mark Curtis, 04/28/15

. After several years of intense systematic research, and toiling with a differentiation protocol, Dr. Doug Melton, and his lab at Harvard University, finally decoded the sequence of genes that needs to be activated to yield mature, insulin-producing beta cells in vitro. While a few investigators have managed to get in the vicinity and generate…Read more

Cell Therapy 2.0 – warts and all

Author: David Kent, 03/16/15

> The last 15 years of stem cell research have been full of hope and promises – some of it delivered upon, most of it not quite there yet, and some of it miserably failed. I guess that is to be expected in a highly experimental area of medicine, but one of the most striking…Read more

The value of a cure

Author: James Smith, 12/11/14

. With contributions from David Brindley. We recently discussed the role that consortia could play in accelerating the timeline of discovering and implementing new treatments, covering the ‘partnering’ aspect of the ‘Partnering for Cures’ conference held in New York City that was referenced. It, therefore, seems appropriate to devote some time to the ‘other half:’…Read more

Regenerative Medicine Deal Review

Author: Mark Curtis, 10/17/13

. Welcome to the first Regenerative Medicine Deal Review, an overview of recent licensing, partnering, and financing activity all exclusively in the regenerative medicine and cell therapy industries. Like my first post ‘Update from the Clinic’, this piece is intended to be a regular contribution that can be used for informational purposes to stay apprised…Read more

Making pancreatic beta cells, Doug Melton style: ISSCR 2013

Author: Angela C. H. McDonald, 06/14/13

. Shortly after I started my PhD in 2009, Time magazine profiled a Harvard Stem Cell Institute researcher, Doug Melton, who dedicated his research program to understanding the development and biology of pancreatic beta cells following the diagnosis of his children with type I diabetes. Over the years, I have followed Melton’s progress towards creating…Read more