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Vascularization: A tissue engineering roadblock

There are currently over 100,000 people in the United States on the waiting list for an organ transplant. Between January and March of 2010, fewer than 7,000 patients received transplants. Imagine, as an alternative to donated live tissue, a tissue-engineered...

A revised map for blood development

Simple diagram that shows the development of different blood cells from  hematopoietic stem cell to mature cells. From Wikipedia. All blood cells arise from the common hematopoietic stem cell and are classified into two lineages: lymphoid cells (B-, T- and Natural...

In the blood – part one

Part one in a series looking at the processes involved in the most clinically applied form of stem cell therapy: hematopoietic stem cell transplantation Leukocytes, or white blood cells (WBCs), are an essential part of the immune system. Produced in the bone marrow,...

A new model to expand blood stem cells

In a Molecular Systems Biology paper released this week, our team at the University of Toronto revealed a new mathematical model that links functional cellular assays to specific model outputs, defines cell-level kinetic parameters such as cell cycle rates and...