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Gene deletion to create insulin-producing cells

Most research on stem cells involves the manipulation of gene expression, to some degree or another. During stem cell differentiation, the expression of specific genes orchestrates the choices cells make along the path from stem cell to adult cell — a process...

Lasting memories of a pancreatic beta cell

Induced pluripotent stem cells (iPSCs) have great memories. They can remember whether they started out as a skin fibroblast, a blood cell or a pancreatic beta cell. Following reprogramming, iPSCs retain epigenetic (DNA packaging) signatures typical of their somatic...