Explaining the hype: CAR T-cells

Author: Sara M. Nolte, 01/15/18

With the start of a new year, I like to take a moment to think about what things in cancer research got me really excited the previous year. Beyond a doubt, that thing for me in 2017 was the first (and second!) FDA approval of a CAR T-cell (chimeric antigen receptor T-cell) therapy as a…Read more

What you get for what you gave: Why yield is an important metric in the development of CGTs.

Author: Sowmya Viswanathan, 01/08/18

  In this month’s blog on addressing specific bioprocess and bioanalytical challenges to develop Cell and Gene Therapies (CGTs), we hear from Dr. Nick Timmins on quantifying performance of CGTs using cell yield, and some of the methods to measure it, as a metric of optimized manufacturing of CGTs. (SV) Nick Timmins is VP, Process…Read more

Right Turn: A new science twist on those old Christmas favourites

Author: Stacey Johnson, 12/22/17

This time of year is special for many reasons, and traditions are a big part of that. It’s risky to mess with traditions; many people look forward to, and value, the familiarity and ritual of repeating something they have done for years, or even decades. You might think that introduction means I’m heading to the Signals archives…Read more

Right Turn: Four STEM women to watch

Author: Stacey Johnson, 12/15/17

  If I say the names Kirsty Duncan, Mona Nemer, Julie Payette and Molly Shoichet, what comes to mind? There are many ways to answer that question, of course, but the answer I’m looking for is that they are all female scientists or engineers who hold significant posts in government with the ability to influence…Read more

Art meets regenerative medicine in the hands of Toronto artist

Author: Guest, 12/14/17

Ann Perry is senior communications officer at Medicine by Design at the University of Toronto. She previously held strategic communications roles in the Ontario government and not-for-profit sector, and was an editorial writer, reporter and editor at the Toronto Star. You can follow Medicine by Design on Twitter @MbD_UofT. Please click here to read the…Read more

Right Turn: CCRM’s holiday science gift guide for kids

Author: Laine Jaremey, 12/08/17

The holidays are right around the corner. If you have a child or pre-teen in your life, the pressure is on to find that perfect gift. Since you’re reading Signals, you probably understand the value of encouraging kids to be enthusiastic about science, technology, engineering and mathematics (STEM). After all, a STEM education, both at…Read more

Second skin: A regenerative medicine approach to treating genetic skin diseases

Author: Nicole Forgione, 12/05/17

  One of my personal highlights from this year’s Till and McCulloch Meetings was attending the “Science for Citizens” panel (reported on in a previous post). Experts including Timothy Caulfield, patient advocate William Brock, and National Post writer Tom Blackwell emphasized the dangers of “fake news” in science and health care. I left that panel…Read more

Right Turn: Canada 2067 – a STEM action plan

Author: Stacey Johnson, 12/01/17

  Eleven months in to 2017, I’m confident you’ve heard of Canada 150: a government-led initiative to celebrate and recognize Canada’s “150th” year – that number is widely disputed by the way. If Canada 150 does not sound familiar, you can find information and December activities here. But have you heard of Canada 2067? Of…Read more

Bioprocessing and bioanalytics

Author: Sowmya Viswanathan, 11/30/17

The recent FDA approvals of Kymriah™ for the treatment of children and young adults with B-cell Acute Lymphoblastic Leukemia, and Yescarta™ to treat adults with certain types of non-Hodgkin lymphoma, and the unanimous endorsement by an FDA advisory committee of a gene therapy (LUXTURNA™)  has energized the fields of cell-and gene-based therapies. (Learn how gene…Read more

Right Turn: Singing his way to (science) fame

Author: Stacey Johnson, 11/24/17

Happy Thanksgiving to our American family, friends and colleagues. It may feel like 2017 didn’t offer quite as much to be thankful for on a global level, but there was one uplifting international event that rocked our world. Despacito. On January 12, 2017, Universal Music Latin released “Despacito” and its music video. According to reliable…Read more