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Sara M. Nolte

Sara Nolte holds a Bachelor of Health Sciences and Masters of Science in Biochemistry & Biomedical Sciences from McMaster University. Her MSc research focused on developing a cancer stem model to study brain metastases from the lung. She then spent a year working on developing cell-based cancer immunotherapies. Throughout a highly productive graduate career, Sara became interested in scientific communication and education, and later pursued a career as a Physician Assistant (PA) in order to build medical expertise. Working as a PA in Emergency Medicine helps her find ways to bridge the gaps between laboratory and clinical science, and to improve scientific and health-related communication with the public. Outside of science, Sara enjoys participating in a variety of sports, and is a competitive Olympic weightlifter hoping to compete at the National level soon!

Posts by: Sara M.


A gene-editing fairy tale: Sleeping Beauty transposons

Author: Sara M. Nolte, 02/14/20

We’ve spent a lot of time swooning over CAR T-cells and CRISPR here at Signals, but recently a potential up-and-coming leading lady in the gene and cancer therapy fields has caught our eye. Our interest was piqued by a recent press release from The Max Delbruck Center for Molecular Medicine (MDC) announcing the continuation of […]

THE GENE: one reader’s reflection on a review of the history of genetics

Author: Sara M. Nolte, 10/11/18

While it’s been years since I’ve been in school or academia, I can’t help but feel nostalgic this time of year, when fall marks the beginning of a new year (and the return of the pumpkin spice latte, mmm!). Many of you are hunkering down in your courses, starting new projects (or trying to put […]

The Betrayal: turning cancer against itself

Author: Sara M. Nolte, 07/30/18

I honestly believe that we’re living in the most exciting time for cancer therapeutics. The past few years (dare I say decades, even?) have pushed the boundaries of cancer treatment from radiation and chemotherapy to the use of cancer-targeted antibodies, oncolytic viruses and the more recent approval of CAR-T cells (see my previous post on […]

Explaining the hype: CAR T cells

Author: Sara M. Nolte, 01/15/18

With the start of a new year, I like to take a moment to think about what things in cancer research got me really excited the previous year. Beyond a doubt, that thing for me in 2017 was the first (and second!) FDA approval of a CAR T-cell (chimeric antigen receptor T-cell) therapy as a […]

‘Bad Luck 2.0’ – the transformation to success

Author: Sara M. Nolte, 09/12/17

Over two years ago, an article published in Science took the Internet and media by storm. The paper, “Variation in cancer risk among tissues can be explained by the number of stem cell divisions,” better known as “The ‘Bad Luck’ Cancer Study,” used mathematical modeling to demonstrate that most cancers were a result of chance […]