Dr. Viswanathan is an Affiliate Scientist at the Krembil Research Institute, University Health Network, and an Assistant Professor at the Institute of Biomaterials and Biomedical Engineering and at the Department of Medicine of the University of Toronto. Her research interest is focused on using anti-inflammatory approaches to target inflammatory diseases including osteoarthritis (OA) using next generation, engineered mesenchymal stromal cells (MSCs), and ex-vivo polarized monocytes/macrophages. Dr. Viswanathan’s lab is focused on bioprocess optimization, bioanalytical techniques and translation of these cell- and gene-based therapies into clinical investigations. Dr. Viswanathan is a co-Principal Investigator of a recently approved trial using autologous MSCs to treat OA patients, a North American first. Dr. Viswanathan co-chairs a Cell Therapy Stakeholder Group that engages Health Canada on cell therapy related policy issues. Dr. Viswanathan is manufacturing team lead for CellCAN, a regulatory and manufacturing advisor for OIRM, and a Canadian expert member of the International Standards Organization (ISO)’s technical committee (TC 276) on cell and gene therapies. Dr. Viswanathan is an elected formal liaison between International Society of Cellular Therapy (ISCT) and ISO.
Posts by: Sowmya
In this month’s blog on addressing specific bioprocess and bioanalytical challenges to develop Cell and Gene Therapies (CGTs), we hear from Dr. Nick Timmins on quantifying performance of CGTs using cell yield, and some of the methods to measure it, as a metric of optimized manufacturing of CGTs. (SV) Nick Timmins is VP, Process…Read more
The recent FDA approvals of Kymriah™ for the treatment of children and young adults with B-cell Acute Lymphoblastic Leukemia, and Yescarta™ to treat adults with certain types of non-Hodgkin lymphoma, and the unanimous endorsement by an FDA advisory committee of a gene therapy (LUXTURNA™) has energized the fields of cell-and gene-based therapies. (Learn how gene…Read more