Signals Blog

Chris Kamel

Posts by: Chris

Genomic instability in iPS cells

They’re promising, but not perfect. Induced pluripotent stem cells are perhaps one of the most studied areas of stem cell research today, as researchers work to improve their method of production, but new findings out of Canada and Finland suggests that the process of reprogramming may cause unwanted and irreversible DNA damage. As such, the […]

Horse-derived iPS cells

We’ve talked often about induced pluripotent stem cells (iPS cells) on this blog — the transformation of adult terminally differentiated cells into stem cells that can differentiate into various lineages — mostly in the context of discoveries in mice and potential applications in regenerative therapy for humans. One thing mentioned less often is the use of stem cell […]

Genetic diversity in leukemia cells

Although tumours are typically thought of as a single entity, the cells that make up a tumour are genetically diverse. The traditional view of cancer progression — in which a tumour arises from a single cell after accumulated mutations — suggests that tumour cells, while genetically diverse due to selective pressures and other evolutionary forces, […]

Chemically induced pluripotent stem cells

Induced pluripotent stem (iPS) cells are generally created by the expression of a small number of key genes to reprogram adult cells into an undifferentiated, pluripotent state. Because some of the transcription factors used for reprogramming are oncogenes, as well as concerns about mutagenesis due to genomic integration, scientists have been searching for improved methods […]

Watching the watchers

Because of some vocal opposition, stem cell research is no stranger to controversy. Usually this comes in the form of protests or government lobbying, but Nature News is reporting the story of a group that is trying to discredit the scientists themselves. The anonymous group, calling themselves Stem Cell Watch, has sent out emails calling […]