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RNA-induction: A new method for iPS cell production

The reprogramming of differentiated adult cells into induced pluripotent stem (iPS) cells is accomplished by the expression of a small number of key genes. This is typically done by introducing DNA either by transfection or with viral vectors. Current methods,...

Stem cells and high throughput screening

High-throughput screening, in which many cell culture conditions can be tested using a combination of robotics, control software, and/or highly sensitive detection, allows researchers to explore new ideas quickly; thousands of combinations can be efficiently tested...

Special delivery: Getting stem cells into the spinal cord

Day two of the World Stem Cell Summit featured a much-anticipated update on a groundbreaking clinical trial launched in January to assess the safety and feasibility of injecting fetal stem cells into the spinal cords of people with Amyotrophic Lateral Sclerosis (ALS)....

Fireside chat with Jim Till and Janet Rossant

What happens when two great scientists sit down for a one-on-one to talk about their work, their mentors and what motivates them? Yes, you get some great chemistry, but more than that, you get a fascinating look at the people and process behind the identification of...

Is 2010 the year of the stem cell Nobel?

For the second year running, mainstream media in Canada and abroad has picked up on Nobel buzz surrounding stem cell scientists James Till and Ernest McCulloch, both Senior Scientists at the Ontario Cancer Institute in Toronto. Speculation surrounding a Nobel prize...

Tread lightly in the valley of death…

Last week, a major kerfuffle erupted in the UK stem cell community as leading scientists and pro stem cell organizations argued that Britain’s range of economic austerity measures would jeopardize their ability to be a major player in translational research. Articles...

Even in pharmaceuticals, it’s an RNA world

In the RNA world hypothesis, RNA based biological life can exist without the need for DNA and proteins to store information, make decisions, and in general, control cells. In 1998, the discovery that small RNAs can play important roles in controlling cells...

Fluid shear stress promotes cell differentiation

The transplantation of stem cells for use in regenerative medicine, where diseased or degenerated tissue is replaced with a new cell source, is an exciting field of research. However, prior to the implementation of a cell therapy, large amounts of cells will be...

In the blood – part two

In my last post, I introduced the use of clinical stem cell therapy in treating multiple myelomas and lymphomas. The treatment focuses blood stem cells, known as hematopoietic progenitor cells (HPCs). By transplanting healthy HPCs into patients, nearly normal white...

What’s in a label?

Replacing dead or dying cells with new, healthy ones is the holy grail of regenerative medicine. Even sustaining damaged cells with toxin-mopping, growth-factor-spewing stem-cell-derived support cells would be a tremendous feat. But while clinical trials have hinted...

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