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Stem cells and high throughput screening

High-throughput screening, in which many cell culture conditions can be tested using a combination of robotics, control software, and/or highly sensitive detection, allows researchers to explore new ideas quickly; thousands of combinations can be efficiently tested...

Even in pharmaceuticals, it’s an RNA world

In the RNA world hypothesis, RNA based biological life can exist without the need for DNA and proteins to store information, make decisions, and in general, control cells. In 1998, the discovery that small RNAs can play important roles in controlling cells...

Fluid shear stress promotes cell differentiation

The transplantation of stem cells for use in regenerative medicine, where diseased or degenerated tissue is replaced with a new cell source, is an exciting field of research. However, prior to the implementation of a cell therapy, large amounts of cells will be...

What’s in a label?

Replacing dead or dying cells with new, healthy ones is the holy grail of regenerative medicine. Even sustaining damaged cells with toxin-mopping, growth-factor-spewing stem-cell-derived support cells would be a tremendous feat. But while clinical trials have hinted...

Enhancing cancer stem cell drugs

When cells are subject certain types of mild stress, it activates a protein called NF-κB and downstream pathways that can lead to future stress resistance in a process called pre-conditioning. This is useful for preparing cells for transplant into harsh environments....

Ghosts of stem cells past

One of the coolest breakthroughs of the last five years is the ability to reprogram adult, differentiated cells into pluripotent cells, effectively allowing us to change one cell type into virtually any other. Reprogramming is achieved by expression of a set of genes...